The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside

Arf6 and its effector AMAP1 are overexpressed in malignant breast cancer cells, and are involved in their invasion and metastasis. We recently revealed that GEP100, a guanine nucleotide exchanging factor, is responsible for the activation of Arf6 which induces invasion and metastasis. GEP100 associa...

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Detalhes bibliográficos
Main Authors: Sabe, Hisataka, Hashimoto, Shigeru, Morishige, Masaki, Hashimoto, Ari, Ogawa, Eiji
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634987/
https://ncbi.nlm.nih.gov/pubmed/19262097
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