P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance

Drug resistance, metastasis, and a mesenchymal transcriptional program are central features of aggressive breast tumors. The GTPase Arf6, often overexpressed in tumors, is critical to promote epithelial–mesenchymal transition and invasiveness. The metabolic mevalonate pathway (MVP) is associated wit...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Hashimoto, Ari, Oikawa, Tsukasa, Hashimoto, Shigeru, Sugino, Hirokazu, Yoshikawa, Ayumu, Otsuka, Yutaro, Handa, Haruka, Onodera, Yasuhito, Nam, Jin-Min, Oneyama, Chitose, Okada, Masato, Fukuda, Mitsunori, Sabe, Hisataka
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828690/
https://ncbi.nlm.nih.gov/pubmed/27044891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201510002
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