P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance

Drug resistance, metastasis, and a mesenchymal transcriptional program are central features of aggressive breast tumors. The GTPase Arf6, often overexpressed in tumors, is critical to promote epithelial–mesenchymal transition and invasiveness. The metabolic mevalonate pathway (MVP) is associated wit...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Hashimoto, Ari, Oikawa, Tsukasa, Hashimoto, Shigeru, Sugino, Hirokazu, Yoshikawa, Ayumu, Otsuka, Yutaro, Handa, Haruka, Onodera, Yasuhito, Nam, Jin-Min, Oneyama, Chitose, Okada, Masato, Fukuda, Mitsunori, Sabe, Hisataka
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2016
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828690/
https://ncbi.nlm.nih.gov/pubmed/27044891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201510002
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