Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer

Acquisition of mesenchymal properties by cancer cells is critical for their malignant behaviour, but regulators of the mesenchymal molecular machinery and how it is activated remain elusive. Here we show that clear cell renal cell carcinomas (ccRCCs) frequently utilize the Arf6-based mesenchymal pat...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hashimoto, Shigeru, Mikami, Shuji, Sugino, Hirokazu, Yoshikawa, Ayumu, Hashimoto, Ari, Onodera, Yasuhito, Furukawa, Shotaro, Handa, Haruka, Oikawa, Tsukasa, Okada, Yasunori, Oya, Mototsugu, Sabe, Hisataka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748122/
https://ncbi.nlm.nih.gov/pubmed/26854204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10656
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