Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer

Acquisition of mesenchymal properties by cancer cells is critical for their malignant behaviour, but regulators of the mesenchymal molecular machinery and how it is activated remain elusive. Here we show that clear cell renal cell carcinomas (ccRCCs) frequently utilize the Arf6-based mesenchymal pat...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Hashimoto, Shigeru, Mikami, Shuji, Sugino, Hirokazu, Yoshikawa, Ayumu, Hashimoto, Ari, Onodera, Yasuhito, Furukawa, Shotaro, Handa, Haruka, Oikawa, Tsukasa, Okada, Yasunori, Oya, Mototsugu, Sabe, Hisataka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4748122/
https://ncbi.nlm.nih.gov/pubmed/26854204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10656
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