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Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity
TP53 mutation (i.e., loss of normal-p53) may evoke epithelial-mesenchymal transition (EMT), which was previously attributed to loss of certain miRNAs. However, not all epithelial cells undergo EMT upon TP53 mutation, and the p53-miRNA axis may not fully explain p53 function in epithelial integrity....
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5785525/ https://ncbi.nlm.nih.gov/pubmed/29371630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20043-7 |
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