ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer

Although KRAS and TP53 mutations are major drivers of pancreatic ductal adenocarcinoma (PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its effector AMAP1 are often overexpressed in different cancers and regulate the intracellular dynamics of integrins and E-cadher...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Hashimoto, Shigeru, Furukawa, Shotaro, Hashimoto, Ari, Tsutaho, Akio, Fukao, Akira, Sakamura, Yurika, Parajuli, Gyanu, Onodera, Yasuhito, Otsuka, Yutaro, Handa, Haruka, Oikawa, Tsukasa, Hata, Soichiro, Nishikawa, Yoshihiro, Mizukami, Yusuke, Kodama, Yuzo, Murakami, Masaaki, Fujiwara, Toshinobu, Hirano, Satoshi, Sabe, Hisataka
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717289/
https://ncbi.nlm.nih.gov/pubmed/31399545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1901765116
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