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P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance
Drug resistance, metastasis, and a mesenchymal transcriptional program are central features of aggressive breast tumors. The GTPase Arf6, often overexpressed in tumors, is critical to promote epithelial–mesenchymal transition and invasiveness. The metabolic mevalonate pathway (MVP) is associated wit...
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| 出版年: | J Cell Biol |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4828690/ https://ncbi.nlm.nih.gov/pubmed/27044891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201510002 |
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