P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance

Drug resistance, metastasis, and a mesenchymal transcriptional program are central features of aggressive breast tumors. The GTPase Arf6, often overexpressed in tumors, is critical to promote epithelial–mesenchymal transition and invasiveness. The metabolic mevalonate pathway (MVP) is associated wit...

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Podrobná bibliografie
Vydáno v:J Cell Biol
Hlavní autoři: Hashimoto, Ari, Oikawa, Tsukasa, Hashimoto, Shigeru, Sugino, Hirokazu, Yoshikawa, Ayumu, Otsuka, Yutaro, Handa, Haruka, Onodera, Yasuhito, Nam, Jin-Min, Oneyama, Chitose, Okada, Masato, Fukuda, Mitsunori, Sabe, Hisataka
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4828690/
https://ncbi.nlm.nih.gov/pubmed/27044891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201510002
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