A PILOT AND FEASIBILITY CLINICAL TRIAL EVALUATING IMMUNO-GENE THERAPY OF MALIGNANT PLEURAL MESOTHELIOMA (MPM) USING INTRAPLEURAL DELIVERY OF ADENOVIRUS- INTERFERON-ALPHA (Ad.hIFN-α2b) IN COMBINATION WITH HIGH-DOSE CELECOXIB AND SYSTEMIC CHEMOTHERAPY

PURPOSE: “In situ vaccination” using immuno-gene therapy has the ability to induce polyclonal anti-tumor responses directed by the patient’s immune system. EXPERIMENTAL DESIGN: Patients with unresectable MPM received two intrapleural doses of a replication-defective adenoviral vector containing the...

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發表在:Clin Cancer Res
Main Authors: Sterman, Daniel H, Alley, Evan, Stevenson, James, Friedberg, Joseph, Metzger, Susan, Recio, Adri, Moon, Edmund, Haas, Andrew R, Vachani, Anil, Katz, Sharyn I, Sun, Jing, Heitjan, Daniel F, Hwang, Wei-Ting, Litzky, Leslie, Yearley, Jennifer H, Tan, Kay See, Papasavvas, Emmanouil, Kennedy, Paul, Montaner, Luis J., Cengel, Keith, Simone, Charles B, Culligan, Melissa, Langer, Corey J, Albelda, Steven M
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970934/
https://ncbi.nlm.nih.gov/pubmed/26968202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2133
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