Phase I Study of Intrapleural Gene-Mediated Cytotoxic Immunotherapy in Patients with Malignant Pleural Effusion

Gene-mediated cytotoxic immunotherapy (GMCI) is an immune strategy implemented through local delivery of an adenovirus-based vector expressing the thymidine kinase gene (aglatimagene besadenovec, AdV-tk) followed by anti-herpetic prodrug valacyclovir. A phase I dose escalation trial of GMCI followed...

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Publicado en:Mol Ther
Autores principales: Aggarwal, Charu, Haas, Andrew R., Metzger, Susan, Aguilar, Laura K., Aguilar-Cordova, Estuardo, Manzanera, Andrea G., Gómez-Hernández, Gregoria, Katz, Sharyn I., Alley, Evan W., Evans, Tracey L., Bauml, Joshua M., Cohen, Roger B., Langer, Corey J., Albelda, Steven M., Sterman, Daniel H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2018
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993936/
https://ncbi.nlm.nih.gov/pubmed/29550074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.02.015
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