The phospholipase A(2) activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages

Peroxiredoxin 6 (Prdx6) is essential for activation of NADPH oxidase type 2 (NOX2) in pulmonary microvascular endothelial cells (PMVECs), alveolar macrophages (AMs), and polymorphonuclear leukocytes. Angiotensin II and phorbol ester increased superoxide/H(2)O(2) generation in PMVECs, AMs, and isolat...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:FASEB J
Main Authors: Vázquez-Medina, José Pablo, Dodia, Chandra, Weng, Liwei, Mesaros, Clementina, Blair, Ian A., Feinstein, Sheldon I., Chatterjee, Shampa, Fisher, Aron B.
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2016
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970605/
https://ncbi.nlm.nih.gov/pubmed/27178323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500146R
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