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A Novel Nontoxic Inhibitor of the Activation of NADPH Oxidase Reduces Reactive Oxygen Species Production in Mouse Lung
1-Hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol (MJ33) is a fluorinated phospholipid analog that inhibits the phospholipase A(2) (PLA(2)) activity of peroxiredoxin 6 (Prdx6). Prdx6 PLA(2) activity is required for activation of NADPH oxidase 2 and subsequent generation of reactive oxygen spe...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3629794/ https://ncbi.nlm.nih.gov/pubmed/23475902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.201079 |
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