A Novel Nontoxic Inhibitor of the Activation of NADPH Oxidase Reduces Reactive Oxygen Species Production in Mouse Lung

1-Hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol (MJ33) is a fluorinated phospholipid analog that inhibits the phospholipase A(2) (PLA(2)) activity of peroxiredoxin 6 (Prdx6). Prdx6 PLA(2) activity is required for activation of NADPH oxidase 2 and subsequent generation of reactive oxygen spe...

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Autores principales: Lee, Intae, Dodia, Chandra, Chatterjee, Shampa, Zagorski, John, Mesaros, Clementina, Blair, Ian A., Feinstein, Sheldon I., Jain, Mahendra, Fisher, Aron B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2013
Materias:
Inflammation, Immunopharmacology, and Asthma
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629794/
https://ncbi.nlm.nih.gov/pubmed/23475902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.201079
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