Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2)

The phospholipase A(2) activity of peroxiredoxin 6 is inhibited by the transition state analog, 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol (MJ33). This activity is required for the activation of NADPH oxidase, type 2. The present study evaluated the effect of MJ33 on manifestations...

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Bibliographic Details
Main Authors: Lee, Intae, Dodia, Chandra, Chatterjee, Shampa, Feinstein, Sheldon I., Fisher, Aron B.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962626/
https://ncbi.nlm.nih.gov/pubmed/24487388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00374.2013
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