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Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia

Lung injury associated with hyperoxia reflects in part the secondary effects of pulmonary inflammation and the associated production of reactive oxygen species due to activation of NADPH oxidase, type 2 (NOX2). Activation of NOX2 requires the phospholipase A2 (PLA2) activity of peroxiredoxin 6 (Prdx...

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Main Authors: Bavneet Benipal, Sheldon I. Feinstein, Shampa Chatterjee, Chandra Dodia, Aron B. Fisher
格式: Artigo
語言:Inglês
出版: Elsevier 2015-04-01
叢編:Redox Biology
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在線閱讀:http://www.sciencedirect.com/science/article/pii/S2213231715000129
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