Inhibition of the phospholipase A(2) activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia

Lung injury associated with hyperoxia reflects in part the secondary effects of pulmonary inflammation and the associated production of reactive oxygen species due to activation of NADPH oxidase, type 2 (NOX2). Activation of NOX2 requires the phospholipase A(2) (PLA(2)) activity of peroxiredoxin 6 (...

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Vydáno v:Redox Biol
Hlavní autoři: Benipal, Bavneet, Feinstein, Sheldon I., Chatterjee, Shampa, Dodia, Chandra, Fisher, Aron B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803794/
https://ncbi.nlm.nih.gov/pubmed/25637741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.01.011
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