Inhibition of the phospholipase A(2) activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia

Lung injury associated with hyperoxia reflects in part the secondary effects of pulmonary inflammation and the associated production of reactive oxygen species due to activation of NADPH oxidase, type 2 (NOX2). Activation of NOX2 requires the phospholipase A(2) (PLA(2)) activity of peroxiredoxin 6 (...

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Publicado en:Redox Biol
Autores principales: Benipal, Bavneet, Feinstein, Sheldon I., Chatterjee, Shampa, Dodia, Chandra, Fisher, Aron B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803794/
https://ncbi.nlm.nih.gov/pubmed/25637741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.01.011
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