Peroxiredoxin 6 Phosphorylation and Subsequent Phospholipase A(2) Activity Are Required for Agonist-mediated Activation of NADPH Oxidase in Mouse Pulmonary Microvascular Endothelium and Alveolar Macrophages

Peroxiredoxin 6 (Prdx6), a bifunctional enzyme with glutathione peroxidase and phospholipase A2 (PLA(2)) activities, participates in the activation of NADPH oxidase 2 (NOX2) in neutrophils, but the mechanism for this effect is not known. We now demonstrate that Prdx6 is required for agonist-induced...

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Main Authors: Chatterjee, Shampa, Feinstein, Sheldon I., Dodia, Chandra, Sorokina, Elena, Lien, Yu-Chin, Nguyen, Su, Debolt, Kris, Speicher, David, Fisher, Aron B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064221/
https://ncbi.nlm.nih.gov/pubmed/21262967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.206623
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