Acidic chitinase primes the protective immune response to gastrointestinal nematodes

Acidic mammalian chitinase (AMCase) is known to be induced by allergens and helminths, yet its role in immunity is unclear. Using AMCase-deficient mice, we show that AMCase deficiency reduced the number of group 2 innate lymphoid cells during allergen challenge but was not required for establishment...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nat Immunol
Main Authors: Vannella, Kevin M, Ramalingam, Thirumalai R, Hart, Kevin M, de Queiroz Prado, Rafael, Sciurba, Joshua, Barron, Luke, Borthwick, Lee A, Smith, Allen D, Mentink-Kane, Margaret, White, Sandra, Thompson, Robert W, Cheever, Allen W, Bock, Kevin, Moore, Ian, Fitz, Lori J, Urban, Joseph F, Wynn, Thomas A
פורמט: Artigo
שפה:Inglês
יצא לאור: 2016
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970463/
https://ncbi.nlm.nih.gov/pubmed/27043413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3417
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