Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis

The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here, using CD11b-Diphtheria Toxin Receptor (DTR) transgenic mice and three models of IL-13-dependent inflammation, fibrosis, and immunity, we show that CD11b(+) F4/80(+) Ly6C+ macrophages are required for the mainte...

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Udgivet i:Mucosal Immunol
Main Authors: Borthwick, Lee A., Barron, Luke, Hart, Kevin M., Vannella, Kevin M., Thompson, Robert W., Oland, Sandra, Cheever, Allen, Sciurba, Joshua, Ramalingam, Thirumalai R., Fisher, Andrew J., Wynn, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626445/
https://ncbi.nlm.nih.gov/pubmed/25921340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2015.34
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