Incomplete Deletion of IL-4Rα by LysM(Cre) Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

Mice expressing a Cre recombinase from the lysozyme M-encoding locus (Lyz2) have been widely used to dissect gene function in macrophages and neutrophils. Here, we show that while naïve resident tissue macrophages from IL-4Rα(flox/delta)LysM(Cre) mice almost completely lose IL-4Rα function, a large...

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Detalhes bibliográficos
Main Authors: Vannella, Kevin M., Barron, Luke, Borthwick, Lee A., Kindrachuk, Kristen N., Narasimhan, Prakash Babu, Hart, Kevin M., Thompson, Robert W., White, Sandra, Cheever, Allen W., Ramalingam, Thirumalai R., Wynn, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161449/
https://ncbi.nlm.nih.gov/pubmed/25211233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004372
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