Incomplete Deletion of IL-4Rα by LysM(Cre) Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

Mice expressing a Cre recombinase from the lysozyme M-encoding locus (Lyz2) have been widely used to dissect gene function in macrophages and neutrophils. Here, we show that while naïve resident tissue macrophages from IL-4Rα(flox/delta)LysM(Cre) mice almost completely lose IL-4Rα function, a large...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Vannella, Kevin M., Barron, Luke, Borthwick, Lee A., Kindrachuk, Kristen N., Narasimhan, Prakash Babu, Hart, Kevin M., Thompson, Robert W., White, Sandra, Cheever, Allen W., Ramalingam, Thirumalai R., Wynn, Thomas A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161449/
https://ncbi.nlm.nih.gov/pubmed/25211233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004372
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk