TNFα/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction

IL-17 and TNFα synergistically induce surface expression of IL-13Rα2 on primary lung fibroblasts, rendering them unresponsive to IL-13. Neutralizing antibodies to IL-13Rα2 restored IL-13-mediated signaling and transcriptome studies confirmed IL-13Rα2 is an IL-13 decoy receptor.

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Bibliografske podrobnosti
Main Authors: Badalyan, Vahe, Addo, Kezia, Thompson, Robert W, Borthwick, Lee A, Fisher, Andrew J, Ort, Tatiana, Myers, Timothy G, Wynn, Thomas A, Ramalingam, Thirumalai R
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186904/
https://ncbi.nlm.nih.gov/pubmed/24954262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.05.019
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