Colitis and intestinal inflammation in IL10−/− mice results from IL-13Rα2-mediated attenuation of IL-13 activity

BACKGROUND & AIMS: The immunoregulatory cytokine interleukin (IL)-10 is required to maintain immune homeostaisis in the gastrointestinal tract. IL-10-null mice spontaneously develop colitis or are more susceptible to induction of colitis by infections, drugs, and autoimmune reactions. IL-13 regu...

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Main Authors: Wilson, Mark S., Ramalingam, Thirumalai R., Rivollier, Aymeric, Shenderov, Kevin, Mentink-Kane, Margaret M., Madala, Satish K., Cheever, Allen W., Artis, David, Kelsall, Brian L., Wynn, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3006653/
https://ncbi.nlm.nih.gov/pubmed/20951137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2010.09.047
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