Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases and Attenuates IL-13–Dependent Fibrosis

Infection with the parasitic helminth Schistosoma mansoni causes significant liver fibrosis and extracellular matrix (ECM) remodeling. Matrix metalloproteinases (MMP) are important regulators of the ECM by regulating cellular inflammation, extracellular matrix deposition, and tissue reorganization....

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Main Authors: Madala, Satish K., Pesce, John T., Ramalingam, Thirumalai R., Wilson, Mark S., Minnicozzi, Samantha, Cheever, Allen W., Thompson, Robert W., Mentink-Kane, Margaret M., Wynn, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175622/
https://ncbi.nlm.nih.gov/pubmed/20181883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903008
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