Acidic chitinase primes the protective immune response to gastrointestinal nematodes

Acidic mammalian chitinase (AMCase) is known to be induced by allergens and helminths, yet its role in immunity is unclear. Using AMCase-deficient mice, we show that AMCase deficiency reduced the number of group 2 innate lymphoid cells during allergen challenge but was not required for establishment...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Vannella, Kevin M, Ramalingam, Thirumalai R, Hart, Kevin M, de Queiroz Prado, Rafael, Sciurba, Joshua, Barron, Luke, Borthwick, Lee A, Smith, Allen D, Mentink-Kane, Margaret, White, Sandra, Thompson, Robert W, Cheever, Allen W, Bock, Kevin, Moore, Ian, Fitz, Lori J, Urban, Joseph F, Wynn, Thomas A
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970463/
https://ncbi.nlm.nih.gov/pubmed/27043413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3417
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