Bispecific anti-HIV-1 antibodies with enhanced breadth and potency

Broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) suppress viremia in animal models of HIV-1 and humans. To achieve potent activity without the emergence of viral escape mutants, co-administration of different bNAbs is necessary to target distinct epitopes essenti...

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發表在:Cell
Main Authors: Bournazos, Stylianos, Gazumyan, Anna, Seaman, Michael S., Nussenzweig, Michel C., Ravetch, Jeffrey V.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970321/
https://ncbi.nlm.nih.gov/pubmed/27315478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.04.050
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