Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity

Broadly neutralizing antibodies (bNAbs) against HIV-1 provide both effective pre-exposure prophylaxis and treatment of HIV-1 infection in murine and non-human primate models, suggesting their potential use in humans. While much is known about the role of variable domains in the neutralization breadt...

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Autores principales: Bournazos, Stylianos, Klein, Florian, Pietzsch, John, Seaman, Michael S., Nussenzweig, Michel C., Ravetch, Jeffrey V.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4167398/
https://ncbi.nlm.nih.gov/pubmed/25215485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.08.023
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