Increasing the Potency and Breadth of an HIV Antibody by using Structure-Based Rational Design

Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show exceptional potency and breadth. We determined structures of NIH45-46, a more potent clonal variant of VRC01, alone and bound to gp120. Comparisons with VRC01–gp120 revealed that a four-residue insertion in CDR...

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Detalhes bibliográficos
Main Authors: Diskin, Ron, Scheid, Johannes F., Marcovecchio, Paola M., West, Anthony P., Klein, Florian, Gao, Han, Gnanapragasam, Priyanthi N. P., Abadir, Alexander, Seaman, Michael S., Nussenzweig, Michel C., Bjorkman, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232316/
https://ncbi.nlm.nih.gov/pubmed/22033520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1213782
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