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Increasing the Potency and Breadth of an HIV Antibody by using Structure-Based Rational Design
Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can show exceptional potency and breadth. We determined structures of NIH45-46, a more potent clonal variant of VRC01, alone and bound to gp120. Comparisons with VRC01–gp120 revealed that a four-residue insertion in CDR...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232316/ https://ncbi.nlm.nih.gov/pubmed/22033520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1213782 |
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