Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions

Organic anion transporting polypeptide (OATP) 1B1 mediates the hepatic uptake of many drugs including lipid-lowering statins. Decreased OATP1B1 transport activity is often associated with increased systemic exposure of statins and statin-induced myopathy. Antimalarial drug chloroquine (CQ) is also u...

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Publicat a:Mol Pharm
Autors principals: Alam, Khondoker, Pahwa, Sonia, Wang, Xueying, Zhang, Pengyue, Ding, Kai, Abuznait, Alaa H., Li, Lang, Yue, Wei
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970216/
https://ncbi.nlm.nih.gov/pubmed/26750564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00763
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