Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents

The sulfonamide class of antibiotics has been in continuous use for over 70 years. They are thought to act by directly inhibiting dihydropteroate synthase (DHPS), and also acting as prodrugs that sequester pterin pools by forming dead end pterin-sulfonamide conjugates. In this study, eight pterin-su...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Zhao, Ying, Shadrick, William R., Wallace, Miranda J., Wu, Yinan, Griffith, Elizabeth C., Qi, Jianjun, Yun, Mi-Kyung, White, Stephen W., Lee, Richard E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4969146/
https://ncbi.nlm.nih.gov/pubmed/27423480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.07.006
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