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Development of a Pterin-based Fluorescent Probe for Screening Dihydropteroate Synthase
Dihydropteroate synthase (DHPS) is the classical target of the sulfonamide class of antimicrobial agents, whose use has been limited by widespread resistance and pharmacological side effects. We have initiated a structure-based drug design approach for the development of novel DHPS inhibitors that b...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3384522/ https://ncbi.nlm.nih.gov/pubmed/21916405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200346e |
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