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Development of a Pterin-based Fluorescent Probe for Screening Dihydropteroate Synthase

Dihydropteroate synthase (DHPS) is the classical target of the sulfonamide class of antimicrobial agents, whose use has been limited by widespread resistance and pharmacological side effects. We have initiated a structure-based drug design approach for the development of novel DHPS inhibitors that b...

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Detalhes bibliográficos
Main Authors: Zhao, Ying, Hammoudeh, Dalia, Lin, Wenwei, Das, Sourav, Yun, Mi-Kyung, Li, Zhenmei, Griffith, Elizabeth, Chen, Taosheng, White, Stephen W., Lee, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384522/
https://ncbi.nlm.nih.gov/pubmed/21916405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200346e
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