Development of a Pterin-based Fluorescent Probe for Screening Dihydropteroate Synthase

Dihydropteroate synthase (DHPS) is the classical target of the sulfonamide class of antimicrobial agents, whose use has been limited by widespread resistance and pharmacological side effects. We have initiated a structure-based drug design approach for the development of novel DHPS inhibitors that b...

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Main Authors: Zhao, Ying, Hammoudeh, Dalia, Lin, Wenwei, Das, Sourav, Yun, Mi-Kyung, Li, Zhenmei, Griffith, Elizabeth, Chen, Taosheng, White, Stephen W., Lee, Richard E.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384522/
https://ncbi.nlm.nih.gov/pubmed/21916405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc200346e
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