Identification and Characterization of an Allosteric Inhibitory Site on Dihydropteroate Synthase

[Image: see text] The declining effectiveness of current antibiotics due to the emergence of resistant bacterial strains dictates a pressing need for novel classes of antimicrobial therapies, preferably against molecular sites other than those in which resistance mutations have developed. Dihydropte...

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Main Authors: Hammoudeh, Dalia I., Daté, Mihir, Yun, Mi-Kyung, Zhang, Weixing, Boyd, Vincent A., Viacava Follis, Ariele, Griffith, Elizabeth, Lee, Richard E., Bashford, Donald, White, Stephen W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076017/
https://ncbi.nlm.nih.gov/pubmed/24650357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500038g
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