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Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents
The sulfonamide class of antibiotics has been in continuous use for over 70 years. They are thought to act by directly inhibiting dihydropteroate synthase (DHPS), and also acting as prodrugs that sequester pterin pools by forming dead end pterin-sulfonamide conjugates. In this study, eight pterin-su...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4969146/ https://ncbi.nlm.nih.gov/pubmed/27423480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.07.006 |
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