The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase

Staphylococcal species are a leading cause of bacterial drug-resistant infections and associated mortality. One strategy to combat bacterial drug resistance is to revisit compromised targets, and to circumvent resistance mechanisms using structure-assisted drug discovery. The folate pathway is an id...

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Bibliographische Detailangaben
Veröffentlicht in:Front Microbiol
Hauptverfasser: Griffith, Elizabeth C., Wallace, Miranda J., Wu, Yinan, Kumar, Gyanendra, Gajewski, Stefan, Jackson, Pamela, Phelps, Gregory A., Zheng, Zhong, Rock, Charles O., Lee, Richard E., White, Stephen W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057106/
https://ncbi.nlm.nih.gov/pubmed/30065703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.01369
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