Validation of chemical compound library screening for transcriptional co‐activator with PDZ‐binding motif inhibitors using GFP‐fused transcriptional co‐activator with PDZ‐binding motif

Transcriptional co‐activator with PDZ‐binding motif (TAZ) plays versatile roles in cell proliferation and differentiation. It is phosphorylated by large tumor suppressor kinases, the core kinases of the tumor‐suppressive Hippo pathway. Phosphorylation induces the cytoplasmic accumulation of TAZ and...

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Bibliographic Details
Published in:Cancer Sci
Main Authors: Nagashima, Shunta, Maruyama, Junichi, Kawano, Shodai, Iwasa, Hiroaki, Nakagawa, Kentaro, Ishigami‐Yuasa, Mari, Kagechika, Hiroyuki, Nishina, Hiroshi, Hata, Yutaka
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968592/
https://ncbi.nlm.nih.gov/pubmed/27009852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12936
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