Validation of chemical compound library screening for transcriptional co‐activator with PDZ‐binding motif inhibitors using GFP‐fused transcriptional co‐activator with PDZ‐binding motif

Transcriptional co‐activator with PDZ‐binding motif (TAZ) plays versatile roles in cell proliferation and differentiation. It is phosphorylated by large tumor suppressor kinases, the core kinases of the tumor‐suppressive Hippo pathway. Phosphorylation induces the cytoplasmic accumulation of TAZ and...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Nagashima, Shunta, Maruyama, Junichi, Kawano, Shodai, Iwasa, Hiroaki, Nakagawa, Kentaro, Ishigami‐Yuasa, Mari, Kagechika, Hiroyuki, Nishina, Hiroshi, Hata, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968592/
https://ncbi.nlm.nih.gov/pubmed/27009852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12936
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