Discovery of high affinity anti-ricin antibodies by B cell receptor sequencing and by yeast display of combinatorial V(H):V(L) libraries from immunized animals

Ricin is a toxin that could potentially be used as a bioweapon. We identified anti-ricin A chain antibodies by sequencing the antibody repertoire from immunized mice and by selecting high affinity antibodies using yeast surface display. These methods led to the isolation of multiple antibodies with...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:MAbs
Egile Nagusiak: Wang, Bo, Lee, Chang-Han, Johnson, Erik L., Kluwe, Christien A., Cunningham, Josephine C., Tanno, Hidetaka, Crooks, Richard M., Georgiou, George, Ellington, Andrew D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Taylor & Francis 2016
Gaiak:
Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968101/
https://ncbi.nlm.nih.gov/pubmed/27224530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1190059
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