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Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening

Immunoglobulin Fc heterodimers, which are useful scaffolds for the generation of bispecific antibodies, have been mostly generated through structure-based rational design methods that introduce asymmetric mutations into the CH3 homodimeric interface to favor heterodimeric Fc formation. Here, we repo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Choi, Hye-Ji, Kim, Ye-Jin, Choi, Dong-Ki, Kim, Yong-Sung
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682967/
https://ncbi.nlm.nih.gov/pubmed/26675656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145349
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