Discovery of high affinity anti-ricin antibodies by B cell receptor sequencing and by yeast display of combinatorial V(H):V(L) libraries from immunized animals

Ricin is a toxin that could potentially be used as a bioweapon. We identified anti-ricin A chain antibodies by sequencing the antibody repertoire from immunized mice and by selecting high affinity antibodies using yeast surface display. These methods led to the isolation of multiple antibodies with...

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Gepubliceerd in:MAbs
Hoofdauteurs: Wang, Bo, Lee, Chang-Han, Johnson, Erik L., Kluwe, Christien A., Cunningham, Josephine C., Tanno, Hidetaka, Crooks, Richard M., Georgiou, George, Ellington, Andrew D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2016
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Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968101/
https://ncbi.nlm.nih.gov/pubmed/27224530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1190059
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