Electrochemical Na(+) and Ca(2+) gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

Coupling of an intracellular Ca(2+) clock to surface membrane ion channels, i.e., a “membrane clock, ” via coupling of electrochemical Na(+) and Ca(2+) gradients (E(Na) and E(Ca), respectively) has been theorized to regulate sinoatrial nodal cell (SANC) normal automaticity. To test this hypothesis,...

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Dettagli Bibliografici
Pubblicato in:Am J Physiol Heart Circ Physiol
Autori principali: Sirenko, Syevda G., Maltsev, Victor A., Yaniv, Yael, Bychkov, Rostislav, Yaeger, Daniel, Vinogradova, Tatiana, Spurgeon, Harold A., Lakatta, Edward G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2016
Soggetti:
Cardiac Excitation and Contraction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967203/
https://ncbi.nlm.nih.gov/pubmed/27208164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00667.2015
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