Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice

Mitochondrial dysfunction is associated with many human diseases and results from mismatch of damage and repair over the life of the organelle. PARK2 is a ubiquitin E3 ligase that regulates mitophagy, a repair mechanism that selectively degrades damaged mitochondria. Deletion of PARK2 in multiple in...

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Published in:Am J Physiol Endocrinol Metab
Main Authors: Costa, Diana K., Huckestein, Brydie R., Edmunds, Lia R., Petersen, Max C., Nasiri, Ali, Butrico, Gina M., Abulizi, Abudukadier, Harmon, Daniel B., Lu, Canying, Mantell, Benjamin S., Hartman, Douglas J., Camporez, João-Paulo G., O'Doherty, Robert M., Cline, Gary W., Shulman, Gerald I., Jurczak, Michael J.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967148/
https://ncbi.nlm.nih.gov/pubmed/27166280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00042.2016
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