Hepatic insulin sensitivity is improved in high‐fat diet‐fed Park2 knockout mice in association with increased hepatic AMPK activation and reduced steatosis

Park2 is an E3 ubiquitin ligase known for its role in mitochondrial quality control via the mitophagy pathway. Park2 KO mice are protected from diet‐induced obesity and hepatic insulin sensitivity is improved in high‐fat diet (HFD)‐fed Park2 KO mice even under body weight‐matched conditions. In orde...

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Vydáno v:Physiol Rep
Hlavní autoři: Edmunds, Lia R., Huckestein, Brydie R., Kahn, Mario, Zhang, Dongyan, Chu, Yanxia, Zhang, Yingze, Wendell, Stacy G., Shulman, Gerald I., Jurczak, Michael J.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854109/
https://ncbi.nlm.nih.gov/pubmed/31724300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14281
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