Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance

OBJECTIVE: PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur during the pathogenesis of obesity-associated fatty liver and contribute to changes in mitocho...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Edmunds, Lia R., Xie, Bingxian, Mills, Amanda M., Huckestein, Brydie R., Undamatla, Ramya, Murali, Anjana, Pangburn, Martha M., Martin, James, Sipula, Ian, Kaufman, Brett A., Scott, Iain, Jurczak, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399260/
https://ncbi.nlm.nih.gov/pubmed/32653576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101051
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