Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1

We previously described 4Dm2m, an exceptionally potent broadly neutralizing CD4-antibody fusion protein against HIV-1. It was generated by fusing the engineered single human CD4 domain mD1.22 to both the N and C termini of the human IgG1 heavy chain constant region and the engineered single human an...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Chen, Weizao, Bardhi, Ariola, Feng, Yang, Wang, Yanping, Qi, Qianqian, Li, Wei, Zhu, Zhongyu, Dyba, Marzena A., Ying, Tianlei, Jiang, Shibo, Goldstein, Harris, Dimitrov, Dimiter S.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966869/
https://ncbi.nlm.nih.gov/pubmed/26963639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1160180
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