Engineered Single Human CD4 Domains as Potent HIV-1 Inhibitors and Components of Vaccine Immunogens

Soluble forms of the HIV-1 receptor CD4 (sCD4) have been extensively characterized for more than 2 decades as promising inhibitors and components of vaccine immunogens. However, they were mostly based on the first two CD4 domains (D1D2), and numerous attempts to develop functional, high-affinity, st...

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Bibliografiske detaljer
Main Authors: Chen, Weizao, Feng, Yang, Gong, Rui, Zhu, Zhongyu, Wang, Yanping, Zhao, Qi, Dimitrov, Dimiter S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165761/
https://ncbi.nlm.nih.gov/pubmed/21715496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05119-11
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