Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains

Soluble forms of the human immunodeficiency virus type 1 (HIV-1) primary receptor CD4 (soluble CD4 [sCD4]) have been extensively characterized for a quarter of a century as promising HIV-1 inhibitors, but they have not been clinically successful. By combining a protein cavity-filling strategy and th...

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Autors principals: Chen, Weizao, Feng, Yang, Prabakaran, Ponraj, Ying, Tianlei, Wang, Yanping, Sun, Jianping, Macedo, Camila D. S., Zhu, Zhongyu, He, Yuxian, Polonis, Victoria R., Dimitrov, Dimiter S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3911630/
https://ncbi.nlm.nih.gov/pubmed/24198429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02566-13
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