Engineered Soluble Monomeric IgG1 CH3 Domain: GENERATION, MECHANISMS OF FUNCTION, AND IMPLICATIONS FOR DESIGN OF BIOLOGICAL THERAPEUTICS

Most of the therapeutic antibodies approved for clinical use are full-size IgG1 molecules. The interaction of the IgG1 Fc with the neonatal Fc receptor (FcRn) plays a critical role in maintaining their long half-life. We have hypothesized that isolated Fc domains could be engineered to functionally...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ying, Tianlei, Chen, Weizao, Feng, Yang, Wang, Yanping, Gong, Rui, Dimitrov, Dimiter S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
Immunology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757179/
https://ncbi.nlm.nih.gov/pubmed/23867459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484154
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