Engineered Soluble Monomeric IgG1 CH3 Domain: GENERATION, MECHANISMS OF FUNCTION, AND IMPLICATIONS FOR DESIGN OF BIOLOGICAL THERAPEUTICS

Most of the therapeutic antibodies approved for clinical use are full-size IgG1 molecules. The interaction of the IgG1 Fc with the neonatal Fc receptor (FcRn) plays a critical role in maintaining their long half-life. We have hypothesized that isolated Fc domains could be engineered to functionally...

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Main Authors: Ying, Tianlei, Chen, Weizao, Feng, Yang, Wang, Yanping, Gong, Rui, Dimitrov, Dimiter S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757179/
https://ncbi.nlm.nih.gov/pubmed/23867459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.484154
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