The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β

Interleukin-1β (IL-1β) plays a key role in autoinflammatory diseases, such as systemic juvenile idiopathic arthritis (sJIA) or cryopyrin-associated periodic syndrome (CAPS). Canakinumab, a human monoclonal anti-IL-1β antibody, was recently approved for human use under the brand name Ilaris®. Canakin...

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Bibliographic Details
Published in:MAbs
Main Authors: Rondeau, Jean-Michel, Ramage, Paul, Zurini, Mauro, Gram, Hermann
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966334/
https://ncbi.nlm.nih.gov/pubmed/26284424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1081323
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